منابع مشابه
Clamping down on mismatches
A sliding clamp complex may help correct DNA replication errors by keeping track of which DNA strand is new and which is the template.
متن کاملClamping Down on Transposon Targeting
The sliding beta clamp subunit of the DNA replication machinery in the bacterium Escherichia coli coordinates multiple functions in the cell beyond genome duplication. In this issue, Parks et al. (2009) find that the beta clamp interacts with the transposition protein TnsE to target the Tn7 transposon to discontinuously replicating DNA at the replication fork.
متن کاملSignal transduction: Clamping down on Src activity
Recent high-resolution structures of members of the Src family of protein-tyrosine kinases illustrate how a series of cooperative intramolecular interactions represses the catalytic activity of these kinases, but allows for their rapid activation by a variety of regulatory inputs.
متن کاملChromosome Segregation: Clamping down on Deviant Orientations
Chromosome segregation depends on proper orientation of sister kinetochores. The protein Csm1 is required for mono-orientation of sister kinetochores at meiosis I in budding yeast. Surprisingly, its homologue in fission yeast appears instead of clamp micro-tubule binding sites together on single mitotic kinetochores so that they all face one spindle pole.
متن کاملCLAMPing down on microtubules in migratory cells
A little-known microtubule-binding protein promotes cell migration during development. Werner et al. fi nd that the protein, CLAMP, stabilizes microtubules at the front of crawling cells and enables the cells to fi t in when they reach their new home (1). Embryonic cells and cancer cells often travel far from their birthplace and may have to traverse barriers to reach their destinations. During...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature20475